{"product_id":"b0gp2k1p5p","title":"CARDIAC AMYLOIDOSIS: PRINCIPLES, DIAGNOSIS, AND MANAGEMENT","description":"\u003cp\u003eHeart failure with preserved ejection fraction. Unexplained left ventricular thickening. Low voltage on ECG that doesn’t match the echo. Bilateral carpal tunnel syndrome years before cardiac symptoms.\u003c\/p\u003e\n\n\u003cp\u003eWhat if we have been missing the diagnosis?\u003c\/p\u003e\n\n\u003cp\u003eCardiac amyloidosis is no longer a medical curiosity. With advances in imaging, molecular typing, and transformative therapies for both AL (light chain) and ATTR (transthyretin) amyloidosis, early recognition is now lifesaving. Yet many clinicians still encounter delayed diagnoses, therapeutic uncertainty, and fragmented care pathways.\u003c\/p\u003e\n\n\u003cp\u003eCARDIAC AMYLOIDOSIS: PRINCIPLES, DIAGNOSIS, AND MANAGEMENT is a comprehensive, clinically grounded, and future-focused reference designed to change that.\u003c\/p\u003e\n\n\u003cp\u003eThis book takes readers from first principles to cutting-edge innovation in a structured, clinically intuitive journey:\u003c\/p\u003e\n\n\u003cp\u003eFoundations: From Misfolded Protein to Failing Heart\u003c\/p\u003e\n\n\u003cp\u003eThe history of amyloidosis—from Virchow’s early observations to modern molecular breakthroughs\u003c\/p\u003e\n\n\u003cp\u003eMechanisms of protein misfolding, fibrillogenesis, and organotropism\u003c\/p\u003e\n\n\u003cp\u003eWhy the heart becomes the target organ\u003c\/p\u003e\n\n\u003cp\u003eChemical classification and the crucial distinction between AL and ATTR\u003c\/p\u003e\n\n\u003cp\u003eEpidemiology, racial disparities, and genetic penetrance\u003c\/p\u003e\n\n\u003cp\u003eClinical Suspicion: Recognizing the “Red Flags”\u003c\/p\u003e\n\n\u003cp\u003eThe mismatch between ECG voltage and wall thickness\u003c\/p\u003e\n\n\u003cp\u003eHFpEF as a common masquerade\u003c\/p\u003e\n\n\u003cp\u003eOrthopedic clues: carpal tunnel, spinal stenosis, tendon rupture\u003c\/p\u003e\n\n\u003cp\u003eAutonomic dysfunction and extracardiac manifestations\u003c\/p\u003e\n\n\u003cp\u003eA practical differential diagnosis including HCM, Fabry disease, sarcoidosis, and more\u003c\/p\u003e\n\n\u003cp\u003eImaging Mastery\u003c\/p\u003e\n\n\u003cp\u003eECG patterns and conduction disease\u003c\/p\u003e\n\n\u003cp\u003eTransthoracic echo basics and advanced strain imaging (the classic “apical sparing” pattern)\u003c\/p\u003e\n\n\u003cp\u003eCardiac MRI with T1 mapping and Late Gadolinium Enhancement\u003c\/p\u003e\n\n\u003cp\u003eNuclear scintigraphy with Tc-99m PYP and Perugini grading\u003c\/p\u003e\n\n\u003cp\u003eSPECT\/CT and PET tracers in clinical and research settings\u003c\/p\u003e\n\n\u003cp\u003eDiagnostic Precision\u003c\/p\u003e\n\n\u003cp\u003eBiomarker staging systems (Mayo, Gilmore)\u003c\/p\u003e\n\n\u003cp\u003eMonoclonal protein screening algorithms\u003c\/p\u003e\n\n\u003cp\u003eExtracardiac and endomyocardial biopsy techniques\u003c\/p\u003e\n\n\u003cp\u003eCongo Red staining, immunohistochemistry pitfalls, and laser microdissection mass spectrometry—the gold standard\u003c\/p\u003e\n\n\u003cp\u003eDisease-Specific Management\u003c\/p\u003e\n\n\u003cp\u003eThe urgency of AL amyloidosis and modern chemotherapy regimens\u003c\/p\u003e\n\n\u003cp\u003eStem cell transplantation and relapsed disease strategies\u003c\/p\u003e\n\n\u003cp\u003eATTR therapies: TTR stabilizers, RNA silencers, and gene editing\u003c\/p\u003e\n\n\u003cp\u003eEmerging anti-amyloid degraders and CRISPR-based approaches\u003c\/p\u003e\n\n\u003cp\u003ePractical Cardiology in Amyloid Patients\u003c\/p\u003e\n\n\u003cp\u003eFluid management within a narrow therapeutic window\u003c\/p\u003e\n\n\u003cp\u003eMedications to avoid—and why\u003c\/p\u003e\n\n\u003cp\u003eAtrial fibrillation, anticoagulation, and device therapy\u003c\/p\u003e\n\n\u003cp\u003eICD controversies and shared decision-making\u003c\/p\u003e\n\n\u003cp\u003eMechanical circulatory support and transplant considerations\u003c\/p\u003e\n\n\u003cp\u003eBeyond the Heart\u003c\/p\u003e\n\n\u003cp\u003eNeurologic, renal, and gastrointestinal management\u003c\/p\u003e\n\n\u003cp\u003eFinancial toxicity and patient advocacy\u003c\/p\u003e\n\n\u003cp\u003ePalliative care integration\u003c\/p\u003e\n\n\u003cp\u003eBuilding a multidisciplinary amyloid center\u003c\/p\u003e\n\n\u003cp\u003eThe future of AI-driven screening and personalized medicine\u003c\/p\u003e\n\n\u003cp\u003eThis is more than a textbook—it is a clinical playbook.\u003c\/p\u003e\n\n\u003cp\u003eWhether you are:\u003c\/p\u003e\n\n\u003cp\u003eA cardiologist managing unexplained HFpEF\u003c\/p\u003e\n\n\u003cp\u003eA hematologist treating plasma cell dyscrasia\u003c\/p\u003e\n\n\u003cp\u003eAn internist encountering subtle red flags\u003c\/p\u003e\n\n\u003cp\u003eA cardiac imager refining diagnostic algorithms\u003c\/p\u003e\n\n\u003cp\u003eA trainee seeking structured mastery\u003c\/p\u003e\n\n\u003cp\u003eOr a healthcare system leader building an amyloid program\u003c\/p\u003e","brand":"ANT","offers":[{"title":"Ebook","offer_id":67937131069476,"sku":"YSL39976","price":73.59,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0805\/2614\/7620\/files\/61PWyYOFj5L._SY1500.jpg?v=1793266311","url":"https:\/\/booktavero.com\/products\/b0gp2k1p5p","provider":"BookTavero","version":"1.0","type":"link"}